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When trying to understand peculiarities that come with complex health conditions, genetic information can provide a key piece of the puzzle. One gene that is getting a lot of attention lately is MTHFR, and for good reason. Often confused with a “less than scientific” expression, it’s actually an acronym for an enzyme integral to one of the most significant biochemical processes in the body, methylation.
Pollutants, poor nutrition, and stress are putting increased demands on methylation processes, as the body works to preserve itself. When an MTHFR variation is present, as it is in almost half the population, the ability to methylate is hindered, increasing health risks. Expert Dr. Ben Lynch has linked the genetic variation, known as a “SNP” (single nucleotide polymorphism), to over sixty conditions. Some are related to how you think and feel, while others are more serious, i.e. heart disease, dementia, and cancer. There are also individuals that have the MTHFR SNP and don’t experience any noticeable symptoms.
MTHFR information can be helpful to target nutritional and lifestyle protocols when struggling with a difficult condition, such as thyroid dysfunction. In other words, nutrition and lifestyle support can be used to offset deficiencies and restore balance. Even without the genetic SNP, having low thyroid hormone levels contributes to diminished MTHFR function. Although it’s a small piece of the puzzle, it could be a big step towards better health, as well as explaining metabolic anomalies.
Methyl tetrahydrofolate reductase (MTHFR) is the name of both the gene and the enzyme that the gene produces. The enzyme is used to convert folic acid and folate into a form that the body can use, i.e. methylfolate, which is important for numerous biological processes. Your MTHFR composition is dependent upon the two genes from your parents. Depending on whether you inherited zero, one or two MTHFR SNPs (pronounced “snips”), functioning may be reduced by as much as 30 or 70 percent. Methylation is also required for:
Glutathione, methylation, and folate are all integrated cycles associated with MTHFR function and are also linked to thyroid-related conditions. Glutathione is the most abundant detoxifier in the body. It keeps inflammation low, acting as armor against disease processes. Individuals with MTHFR mutations are more vulnerable to stress, toxins, and illness, due to diminished glutathione levels. Research studies show a direct correlation between a breakdown in the glutathione system and autoimmune diseases, such as Hashimoto’s. Autoimmune disease is linked to leaky gut, yet in order to have a healthy gut, maintenance of glutathione levels is necessary.
Nutritional and pharmaceutical recommendations are generally based on the assumption that all systems are functioning at optimal levels. The topic of MTHFR is a good example of how this thinking can falter, and why some people are more sensitive. Folate, B6, and B12 are revered as the most important vitamin “co-factors” in the methylation process, however, riboflavin also plays a key role. Let’s look at how it all fits together:
Folate: Folic acid is the synthetic form of folate used to fortify foods, yet it requires MTHFR for the conversion to a useable form. With the abundance of folic acid in processed foods and vitamin supplements, some are concerned. Without MTHFR, folic acid can pile up potentially resulting in the following:
Riboflavin: Riboflavin (vitamin B2) is a cofactor in the conversion of MTHFR. First, the body must convert riboflavin to its useable form, FAD, and the thyroid hormone thyroxine is necessary for this to occur.
Thyroid: Thyroxine (T4) is the hormone the thyroid releases into the bloodstream, where it travels to organs such as the liver and kidneys. The hormone then converts to its active form, T3, which is used by the cells. Thyroxine has important roles in digestion, brain, heart, muscle and bone health, making it one of the most important hormones we have. The body is designed to tightly regulate levels of thyroxine in the bloodstream. However, it often becomes derailed and conditions such as hyperthyroidism (overactive thyroid) or hypothyroidism (underactive) can result. When thyroxine is low, less is available to convert riboflavin, to a form needed for MTHFR. Therefore, folate metabolism, methylation, and everything within its sphere of influence is affected. Should defective MTHFR functioning exist due to a genetic mutation, the consequences may potentially be exaggerated further.
Since MTHFR is only one type of gene that makes up your unique profile, it’s important to work with a qualified health professional to see how it may be relevant to you. In the meantime here are some tips:
Despite the wealth of research pertaining to MTHFR and the biological impacts touched on here, the information is considered new and controversial in mainstream medicine. Many physicians downplay its role in health and disease. If you are struggling with thyroid disorders or suspect MTHFR is affecting you, it is important to seek out a supportive healthcare professional that is open to addressing your needs.
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Ben Lynch. MTHFR Mutation. MTHFR and Thyroid Conditions. Available at: www.mthfr.netAccessed on July 30, 2016.
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Holtorf Medical GroupThe Holtorf Medical Group specializes in optimizing quality of life and being medical detectives to uncover the underlying cause of symptoms, rather than just prescribing medications to cover-up the symptoms. We are experts in natural, prescription bioidentical hormone replacement and optimization, complex endocrine dysfunction, fibromyalgia, chronic fatigue syndrome and Lyme disease. We’ve dedicated our practice to providing you the best in evidenced-based, integrative medicine that’s not only safe and effective, but provides measurable results.
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