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Low Dose Naltrexone

Low Dose Naltrexone, also known as LDN, is becoming widely used among the medical community to treat infection and modulate the body’s immune system.

LDN balances your immune system by turning off the cells that cause autoimmunity and diminishing the release of inflammatory and neurotoxic chemicals in the brain. By boosting the immune system, it activates the body’s own natural defenses, thereby stimulating immune function in patients with immunodeficiency and reducing antibody production in patients with excessive antibody production, such as Hashimoto’s thyroiditis and Graves’ disease.

LDN is known to improve the abnormal inflammation and immune dysfunction seen with conditions, such as Hashimoto’s Thyroiditis and Graves’ disease. It actually works to improve the reduced tissue T3 levels, thyroid resistance, thyroid transport and leptin resistance in these disorders, particularly autoimmune thyroiditis (Hashimoto’s).

LDN also works with your body’s immune system through its interactions with your body’s endorphins – peptides produced in the brain and adrenal glands that act as the body’s natural painkiller. The major role of LDN is to block the body’s opioid receptors for just a very few hours. Those are the same receptors used by the body’s endorphins. The body responds to this by greatly increasing its endorphin production, and those higher levels last all day – far after the blockade by LDN has ended. Endorphins turn out to be the major normalizer of your immune system.

Though most commonly referenced in relation to you mood, endorphins also play a role in pain relief, growth of cells and angiogenesis (the growth of blood vessels that feed a tumor). As LDN inhibits endorphin production and allows your body to naturally produce more, stimulation of the immune system occurs, pain reduces, and overall sense of well-being is improved. Higher doses can also aid in weight loss.

The experience of people who have autoimmune diseases and who have begun LDN treatment has been remarkable. Many of our patients with autoimmune conditions report significant improvements in their symptoms – particularly fatigue, pain, mood and spasm – after they start taking LDN. LDN is inexpensive, easy to administer, and virtually free of side effects.

In most autoimmune diseases the disease progression halts and symptoms are reduced. While you are sleeping LDN blocks the production of endorphins for several hours. The brain then thinks that there is a shortage of endorphins and signals for the production of many more. The resulting increase in available endorphins will modulate the immune system and results in the reduction of both inflammation and thyroid antibodies. In general, people with diseases that are largely triggered by a deficiency of endorphins or are accelerated by a deficiency of endorphins, experience major therapeutic action of LDN.

Additionally, patients experiencing fatigue, pain, muscle weakness and cognitive dysfunction show vast improvements – up to 90%. LDN has also been shown to reduce symptoms associated with fibromyalgia by 30%. In many of our patients, treatment with LDN has also shown improvement in overall satisfaction with life and improvement in mood.

LDN also offers protective benefits against neurodegenerative diseases, where chronic inflammation is often the underlying cause. With LDN’s antioxidant properties, it reduces the effects of free radicals throughout your body, thereby reducing chronic inflammation and reducing disease progression. The body’s cells and systems then begin to work together to help the body heal itself and often times patients experience remission in signs and symptoms of their condition.

At Holtorf Medical Group, LDN is commonly used as a treatment option for our patients suffering from chronic infections, chronic fatigue syndrome, fibromyalgia, Crohn’s disease, central nervous system disorders, any immune disease, and thyroid-related conditions. LDN is a prescription medication that works to reactivate cells and normalize your body’s immune system.

Our Services

Low Dose Immunotherapy

Low dose immunotherapy, (LDI), is a revolutionary treatment that has been shown to provide dramatic relief of symptoms and improvement in health for patients with a wide range of chronic illnesses, including Lyme disease, chronic fatigue syndrome, Fibromyalgia, Hashimoto’s, Multiple Sclerosis, and more.

Low Dose Allergen

Low dose allergen treatment (LDA) is a safe and effective method of immunotherapy used for treating food and environmental allergies. Far different from other allergy treatments, LDA contains unique antigens that help restore your body’s immune tolerance to the environment outside and inside your body.

Low Dose Naltrexone

Low Dose Naltrexone, also known as LDN, is becoming widely used among the medical community to treat infection and modulate the body’s immune system. LDN balances your immune system by turning off the cells that cause autoimmunity and diminishing the release of inflammatory and neurotoxic chemicals in the brain.

Pulsed Electro-Magnetic Frequency

Pulsed electromagnetic frequency (PEMF) is most commonly known to be used as a reparative technique in the field of orthopedics for the treatment of non-union fractures, failed fusions, and depression. With over 40 years of clinical studies, researchers suggest that the pulsed signal in PEMF activates the body’s chemistry to heal more rapidly.


Our line of nutritional supplements is developed with our patients needs in mind and with the understanding that no one pill works for everyone. Developed by Dr. Holtorf, our proven formulas provide superior results and fit the various needs and tolerances of our patients. The unique formulas and quality ingredients within Holtraceuticals can help relieve your symptoms and restore your health.

Prolozone Therapy

Prolotherapy is an inflammation-reducing injection intended to strengthen ligaments or tendons, and medical-grade ozone therapy is used to increase the amount of oxygen in your blood cells to fight infections and increase energy levels. The combination of these three treatment modalities has provided exceptional results for patients suffering from chronic pain, degenerative disease, and compromised immune systems.

Peptide Therapy

Peptides play a major role in how your body responds to diet and exercise, and adequate peptide levels are imperative to your health. One of the great benefits of therapeutic peptides is that they can be customized to any cellular processes, and studies have shown they may be easier for the body to absorb because of their elemental nature.


At Holtorf Medical Group all patients are encouraged to get a full blood panel and in-office testing so our providers have insight into uncovering the root cause of symptoms. Your physician will discuss the best testing protocol for you to help uncover the root cause of symptoms. Testing may include blood work or additional diagnostic tools.

Bioidentical Hormone Replacement Therapy

BHRT are structurally identical to hormones that are produced by the human body, with many long-term benefits such as maintaining bone density, reduce incidences of breast and uterine cancers and lower the risk of heart disease, strokes, and dementia.

IV Therapy

Our doctors use a wide range of custom IV therapies that are individually tailored to the needs of each patient. When therapies are given intravenously (IV), without the limitations of oral supplements, they are much more effective with major improvements often seen in a short period of time. IV packages are also available for Energy, Immunity, Ozone, Gut, Wellness, Neuro/Mitochondria, Detox, and Adrenals.

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