Everything You Need to Know About Melatonin

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Of the body’s many hormones, melatonin is perhaps one of the most widely known. This is primarily due to its notoriety as a safe, effective, and natural sleep aid. However, in addition to supporting sleep, melatonin also has other qualities that encourage greater wellness. Read on to learn about the basics of melatonin, its role as a sleep regulator, and its many other health benefits.

What is Melatonin?

Melatonin is a hormone produced by the pineal gland located near the center of the brain. This pinecone-shaped piece of the endocrine system is responsible for regulating our circadian rhythm or wake/sleep cycle. A great deal of the pineal gland’s influence on sleep is exerted through the release of melatonin. Depending on the amount of melatonin in our system, we feel more tired or alert. Increased melatonin encourages sleep while reduced values allows for wakefulness.

Melatonin values are dictated in part by the amount of light that enters our retina. The less light present, the more our melatonin values increase. Conversely, as exposure to light increases, the release of melatonin decreases. This is why, in healthy systems, melatonin values are highest during the night and at their lowest during the day.

Light is not the only factor regarding the amount of melatonin in our system. Traveling through time zones, irregular work hours, stress, poor vision, exposure to blue light (such as that emitted by TVs, computers, and phones), consumption of alcohol, caffeine, or tobacco, and the use of certain medications can all contribute to irregular melatonin values. Such dysregulation can result in a variety of issues with the most prominent pertaining to sleep quality.

The Sleep-Regulating Role of Melatonin

Melatonin is also called the sleep hormone and for good reason. The hormone plays an essential role in maintaining the circadian rhythm. An imbalance or deficiency of melatonin can dysregulate the wake/sleep cycle thereby triggering a significant and long-lasting decline in sleep quality. Chronic sleep difficulties such as those caused by a lack of melatonin can lead to serious health issues including diabetes, heart disease, high blood pressure, adrenal fatigue, and other chronic disorders.

Contrasting the harmful effects of deficiency, multiple studies show that maintaining proper melatonin values encourages higher quality sleep, helps people fall asleep faster, discourages sleep interruptions, and promotes feeling well-rested throughout the day. For this reason, melatonin supplements are frequently employed by those who travel and suffer from jet lag. However, anyone wanting to improve their sleep quality may benefit from supplementing with melatonin.

Learn more about the importance of quality sleep here.

Other Important Benefits of Melatonin

Although its most well-known benefits relate to sleep quality, melatonin may also support other important areas of wellness. Some of the other systems and functions positively affected by melatonin are discussed below.

Antioxidant Activity

Animal studies show that melatonin stimulates the production of glutathione peroxidase. This enzyme is considered to be a powerful protectant. This is because it supports the breakdown of free radicals and has anti-inflammatory and immune-boosting qualities. Because melatonin encourages glutathione activity, supplementation support the prevention of cancers and various conditions relating to the heart and brain. Furthermore, studies suggest the antioxidant support provided by melatonin may help heal stomach ulcers, improve gastroesophageal reflux disease (GERD), and alleviate heart burn.

Eye Health

The antioxidant benefits of melatonin also help protect against eye disease including age-related degeneration. In fact, maintaining appropriate melatonin levels has been shown to protect eye health. One study found that regular supplementation with melatonin on a daily basis helped protect retinas and limit eye degeneration.

Treating Tinnitus

Tinnitus causes a constant ringing sound or sensation in the ears. Patients with tinnitus most often experience this when there is little ambient noise or while falling asleep. Studies show that supplementing with melatonin may reduce symptoms of tinnitus, thereby making it easier to fall asleep and improving sleep quality throughout the night.

Immune Function

Some studies suggest that melatonin may act as an immune buffer allowing for more stable immune activity in the presence of immunosuppressants. The anti-inflammatory quality of melatonin helps prevent excess immune activation thereby limiting the risk of inflammation-related damage. It is posited that the regulatory qualities of melatonin may prove to be useful for treating many chronic disorders.

How to Supplement Safely with Melatonin

Perhaps the best way of acquiring the many benefits of melatonin is through supplementation. There are several viable methods of supplementing with melatonin. However, sublingual delivery is considered to be one of the safest and most effective because it allows for greater absorption which facilitate faster results. When selecting a melatonin supplement, be sure to choose a quality product such as HoltraCeuticals’ Melatonin.


Melatonin is considered to be an exceptionally safe supplement. However, melatonin may interact with other medications including antidepressants, birth control medications, blood pressure regulators, blood thinners, steroids, and immunosuppressants. As with all supplements, speak with a doctor before supplementing with melatonin to avoid any possible negative interactions. Some patients who take melatonin as a sleep aid complain of morning grogginess. This is indicative that the dose is too high and can likely be resolved by simply reducing the dose.

Maintaining Your Health with Melatonin

Although melatonin is renowned for its sleep-supporting qualities, there are many other important benefits that it provides. Maintaining healthy values of melatonin through supplementation can improve multiple areas of wellness including immune function, eye health, and may even protect against serious illness. If you want to increase the quality of your sleep and overall wellness, consider using a superior melatonin supplement such as HoltraCeuticals’ Melatonin. 


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About Holtorf Medical Group

The Holtorf Medical Group specializes in optimizing quality of life and being medical detectives to uncover the underlying cause of symptoms, rather than just prescribing medications to cover-up the symptoms. We are experts in natural, prescription bioidentical hormone replacement and optimization, complex endocrine dysfunction, fibromyalgia, chronic fatigue syndrome and Lyme disease.

We’ve dedicated our practice to providing you the best in evidenced-based, integrative medicine that’s not only safe and effective, but provides measurable results.